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Retinoids (retinol and its derivatives) drive cell turnover and directly regulate gene expression in a way that's supported by decades of clinical data

EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells
Int Rev Cell Mol Biol 281:129159

The program predicted that the BBB would not be permeant to the compounds (Table 5)
