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[1] The consequences of untreated deficiency far outweigh the inconvenience of mild, manageable gastrointestinal symptoms

Despite the obscurity of the causal relationship, the loss of barrier integrity is considered to contribute to inflammatory bowel disease, obesity, and metabolic disorders

At a Glance When treating pernicious anemia, initial "loading" B12 injections are given frequently to rapidly refill dangerously empty stores and prevent nerve damage

This more fundamental approach may help maintain metabolic health over time but does not produce the acute appetite suppression and weight loss effects of receptor agonists