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In astrocytes, the itaconate required for such an inhibition could be generated by hydrolysis from uptaken OI, as reported for other cells [49]
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In addition, low IGF-1 subjects in a study were found to possess up-regulated fatty acid metabolism along with down-regulated GLUT-1 gene (in charge of glucose uptake in erythrocytes, brain endothelial cells, eye, peripheral nerve and also responsible for materno-placental glucose transfer) [210]
The term bacteriostatic refers to its ability to inhibit bacterial growth without necessarily killing existing bacteria
