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In addition to obesity, IR and diabetes, TMAO is also reported associated with other metabolic dysregulations that related to MAFLD, including dyslipidemia ( The Underlying Mechanisms of TMAO in the Development of MAFLD Although TMAO has been shown to be linked to MAFLD, the molecular mechanisms of TMAO remain obscure

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Am J Physiol Renal Physiol 317(6):F1680-F94 2019 PMC6962515 Coleman M, Orvis A, Wu TY, Dacanay M, Merillat S, Ogle J, Baldessari A, Kretzer NM, Munson J, Boros-Rausch AJ, Shynlova O, Lye S, Rajagopal L, Adams Waldorf KM