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Angelini C, et al
In contrast to autoimmune models, the cuprizone model is a toxin-induced, reversible demyelination model with selective cell death of myelingenerating oligodendrocytes leading to demyelination associated with a characteristically strong microglia response but minimal blood brain barrier (BBB) damage and peripheral immune cell infiltration (Berghoff et al., 2017)
A complete blood cell count was performed on each rabbit prior to anesthesia on Day 0, and again on Days 7 and 14, to monitor for any systemic abnormalities [2]
10.1016/j.cbi.2010.10.017 [DOI] [PubMed] [Google Scholar] Chen Z., Huang C., Ding W
