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6-phosphofructose-2-kinase/fructose-2, 6-bisphosphatase (PFK2) isomer (L-PFK2) was induced by M1 activation, converted into a more active form (u-PFK2), and led to the accumulation of fructose-2, 6-diphosphate, which promoted intracellular aerobic glycolysis ( In brief, we might consider that metabolic events in classically activated macrophages serve a dual purpose: they rapidly provide energy and reduction equivalents to fuel bactericidal activity, and they directly participate in transcriptional regulation to shape immune responses

[DOI] [PMC free article] [PubMed] [Google Scholar] 662.Joshi P., Perni M., Limbocker R., Mannini B., Casford S., Chia S., Habchi J., Labbadia J., Dobson C.M., Vendruscolo M

Given that IBD serves as a precursor to CAC, it appears that the role of chronic inflammation in tumorigenesis is more pronounced, as chronic inflammation is associated with the accumulation of DNA damage

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