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Noteworthy, the administration of DHA (daily doses of 300 mg/kg) combined with T3 (0.05 mg/kg) to rats increased significantly the content of RVD1 and RVD2 in the liver, but left unchanged that of RVE1 and RVE2, indicating a synergistic effect compared to treatment with DHA alone and T3 alone ( Omega-3 PUFA-Based Nutraceuticals in the Setting of Thyroid Disorders: Experimental Setting Experimental studies that have evaluated the thyroidal effects of the omega-3 PUFA (137143) are summarized in Table 5

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