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The structural similarity to insulin explains the ability of IGF-1 to bind (with low affinity) to the insulin receptor

Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants
Making Informed Supplement Choices Always consult a healthcare practitioner experienced in histamine intolerance to determine which supplements are most appropriate for your needs
doi: 10.1016/j.cell.2005.01.029
