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Also, overexpression of dominant-negative PPAR in murine ATII cells induced emphysema with increased inflammatory cytokines, MMPs, and accumulation of myeloid-derived suppressor cells (MDSCs) in the lungs and circulation system (37)

We further analyzed the expression of the rate-limiting key enzyme in each pathway (GPX4 for the glutathione pathway, HMG-CoA reductase [encoded by HMGCR ] for the mevalonate pathway, and TrxR [encoded by TXNRD1 ] for the thioredoxin pathway) in another single-nuclei dataset comprised of 22 NB patient tumors 32

GR, NADPH $$ The kinetics of glutathione peroxidases are dependent on whether the enzyme is selenium or non-selenium containing