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Studies have consistently reported that inhibiting NNMT activity or downregulating NNMT expression leads to significant increases in NAD + levels in mouse adipocytes (Neelakantan et al., 2018) and hepatocytes (Song et al., 2020)

In fact, according to the National Institutes of Health, nearly 1 in 5 adults over 60 and up to 15% of the general population are estimated to be deficient in vitamin B12

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