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Abstract N -nitrosamine (NA) impurities in pharmaceuticals represent cohort of concern compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation

Use aseptic technique during preparation and reconstitution (if applicable)

The evidence consistently demonstrates that semaglutide is generally well-tolerated, with side effects that are predominantly gastrointestinal, mild-to-moderate in severity, transient in duration, and manageable through evidence-based strategies

Minimal Discomfort: Most clients experience only a quick pinch during the injection, with the entire visit lasting less than 10 minutes