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Description
1997 Jun;38(6):563-76

Acidity of the urine may also play a part, with drugs becoming ionised and trapped in the distal tubule this is the same principle that occurs in neurons in the mechanism of action for local anaesthetics (LA)

S2CID 38333954

Four-month-old male Sprague-Dawley rats were used as the blood source for the metabolism studies
