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Oxygen could be utilized for downregulation of the loop gain
Noweir, Industrial Engineering Department, College of Engineering, King Abdul Aziz University, Jeddah, Saudi Arabia Professor G

Li G, Xu Y, Wang S, Yan W, Zhao Q, Guo J

This has been reported as a major resistance mechanism against cDDP in several types of cancer [64, 65] and is believed to justify cell death when repairs are not possible [66]