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Oxid Med Cell Longev 2021:116

The biomarkers which had the effect sizes that were significant comprised of 28 biomarkers which are in descending order of the effect size given as: CTPN (SMD 37.93, p = 0.03), TG (SMD 16.60, p = 0.0007), BG (SMD 7.54, p = 0.00001), TC (SMD 7.38, p = 0.009), HDL (SMD -5.84, p= 0.0002), LDH (SMD 5.66, p = 0.0005), IL-6 (SMD 5.49, p = 0.00001), AGEs (SMD 5.43, p = 0.004), MDA (SMD 4.78, p = 0.00001), HW (SMD 4.73, p = 0.05), GSH (SMD -4.60, p = 0.009), IL-1 (SMD 4.44, p = 0.003), EF% (SMD -4.13, p = 0.00001), CC3 (SMD 3.91, p = 0.002), NLRP3 (SMD 3.59, p= 0.03), CK-MB (SMD 3.28, p = 0.004), FB% (SMD 3.25, p = 0.01), NF-KB (SMD 3.13, p = 0.0001), HMGB1 (SMD 3.00, p = 0.0001), FS% (SMD -2.91, p= 0.00001), COL III (SMD 2.43, p = 0.01), TLR4 (SMD 2.38, p = 0.009), HW/BW (SMD 2.31, p = 0.007), pJNK (SMD 1.87, p = 0.0001), BW (SMD -1.74, p= 0.05), LVIDs (SMD 1.64, p = 0.04), TGF-1 (SMD 1.50, p = 0.05), and TNF-A (SMD 1.11, p = 0.03)

Radiesse (calcium hydroxylapatite) is a thicker, calcium-based filler designed for deeper facial areas like the jawline and cheeks

Desalniettemin toont onderzoek aan dat de schadelijkheid van koper ongebruikelijk is bij topicale toepassing en zelfs nog zorgwekkender is bij orale inname of intraveneuze toediening