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For example, due to the downregulation of genes for purinergic receptors (e.g., P2ry12 ) and potassium leak channels (e.g., Thik-1 ) in aged mice, the ability for microglia to sense hyperactive neurons and migrate toward them in order to facilitate rapid repolarization would be reduced, impairing their beneficial modulation (Hickman et al., 2013

Alcoholism, Clinical and Experimental Research , 26 (8 Suppl), 26S-31S

That's what alpha brainwaves feel like

46,47 Binding of IREs with IRPs is well regulated by iron concentration
