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PMID: 37 GuanPRuanQLiJXiMQiWKoKIet al
Melatonin, on the other hand, activates both the Nrf2ARE and AMPKSIRT1 pathways, leading to upregulation of antioxidant enzymes such as HO-1, NQO1, and SOD, stabilization of mitochondrial membrane potential, and inhibition of cytochrome c release (84, 85)
Reduce it with therapy, exercise, journaling, and socialization to ease symptoms
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