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Interestingly, the presence of astrogliosis, hallmark of neuroinflammation, had been previously reported in ADHD animal model (Sanches et al
Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus
Iron supplementation, a well-established intervention for restoring systemic iron balance and correcting iron-deficiency anaemia [63] , may similarly prove beneficial within the central nervous system
Notably, iron-bearing proteins such as Cytochrome P450 enzymes, Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), and subunits of the mitochondrial electron transport chain generate superoxide radicals (O 2 )
