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These symptoms are linked to degeneration in serotonergic and noradrenergic circuits, particularly in the raphe nuclei and locus coeruleus, and may manifest years before classical motor signs (Lee et al., 2022
In muscle cells, mTORC2 influences muscle fiber types by regulating mitochondrial dynamics and altering mitochondrial fission and accumulation, thereby affecting cellular metabolism
Curr Opin Struct Biol 18(6):682689 de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family
(1995) Reverse mutation assay Ames test using Salmonella typhimurium
