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IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK

A 54-year-old woman with dizziness and falls

doi: 10.3389/fmicb.2025.1677102 Received 31 July 2025 Accepted 31 October 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Gregg Pettis, Louisiana State University, United States Reviewed by Jong Hyun Ham, Louisiana State University, United States Cong Zhang, Qingdao Agricultural University, China Updates Copyright 2025 Shigeta, Shiraishi, Schroll, Lauer, Keppler, Sakai and Yurimoto

For example, reduced glutathione, the active form of this antioxidant, becomes oxidised (deactivated) as a result of its antioxidant activity, and so requires reduction through glutathione reductase to regain its antioxidant capacity
