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The safety database, while extensive for clinical trials, represents limited duration and population diversity compared to the variability encountered in clinical practice
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

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In addition to alanine, a standard blood biomarker in MDs (Shaham et al., 2010), patients with primary mitochondrial respiratory chain disease also have significantly elevated levels of BCAAs (Vockley and Ensenauer, 2006)
