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The ultimate goal of this effort is to promote patient benefit and alleviate the high global burden of depression

Parellada, M., Llorente, C., Calvo, R., Gutierrez, S., Lzaro, L., Graell, M., Guisasola, M., Dorado, M

JAMA 1973

For example, grapefruit medications can act as competitive inhibitors for cytochrome P450 3A4 enzyme (CYP3A4), resulting in reduction of drug metabolism such as simvastatin and increased toxicity in plasma levels (Lee et al., 2016)
