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Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension
The annulus fibrosus, having significantly weaker compression resistance than tensile resistance, gradually develops structural damage under continuous high pressure, manifesting as overall bulging beyond the endplate boundaries (visible as disc bulging on imaging)
A consistently dark or unusual color could be a sign of a kidney issue, such as urine color and kidney disease, and should be evaluated by a medical professional
Aging: Oxidative Stress and Dietary Antioxidants
