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71 Interestingly, metabolite profiling of cells treated with Cu ionophore presents a time-dependent increase in the dysregulation of many TCA cycle-associated metabolites, and inhibiting the electron transport chain complexes I and II significantly reduced Cu-induced cell death

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doi: 10.1002/art.42286

The glycocalyx on the apical surface of endothelial cells is primarily conformed of glycoproteins and proteoglycans that provide a physical, chemical and electrostatic boundary between the vascular wall and circulating blood components