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789 PCPs are wellsituated to detect dementia because they often have longstanding relationships with patients 790 , 791 and may witness clinical manifestations of cognitive declineboth overt functional and communication changes and subtle signs, such as irregularities in medication or appointment adherence, loss of control of chronic disease, weight loss, or increased emergency department visits or hospitalizations

Finally, it should be mentioned that RGD-containing scaffolds used to deliver growth factors, such as BMP-2 to promote bone regeneration in experimental fracture models, exist with favourable results [150]

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