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doi: 10.1038/nature14344 [DOI] [PMC free article] [PubMed] [Google Scholar] 61
The inability to acquire cysteine through xCT may force cancer cells to use the TSS pathway, less common extracellular dipeptides, or extracellular glutathione to produce cysteine for proliferation [5,30,50,91]
Intriguingly, genes in cluster 2 were enriched in pathways related to non-small cell lung cancer (GADD45G, CDKN1A, PRKCA), transcription misregulation in cancer, and the estrogen signaling pathway (Figure S5O)
doi: 10.1542/peds.2005-2824 19
