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In this report, we test this hypothesis by treating the HRAS G12V -transformed ovarian epithelial cells, mutant KRAS -harboring pancreatic and colon cancer cells of mouse and human origins, as well as cancer xenografts, with diphenyleneiodonium (DPI) and buthionine sulfoximine (BSO) combination, which inhibit NOX activity and glutathione biosynthesis, respectively

Upregulation and release of S100 to the extracellular matrix could also initiate interaction with RAGE that eventually activates NF-B, inducing the production of pro-inflammatory cytokines and migration of neutrophils, monocytes, and macrophages (Xia et al., 2018)

Intriguingly, both Sertoli cells and germ cells express L-CPT I and M-CPT I, implying that carnitine might travel from the bloodstream to Sertoli cells and germ cells

As a key antioxidant, GSH supports innate immunity by modulating redox-sensitive pathways involved in inflammation and host defense (6)