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Some other factors like illnesses, chronic colds, pollution, smoking and inflammatory conditions also lead to excessive usage of glutathione and hence, its depletion

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Interactions of air pollutants with the respiratory mucosa The respiratory system is a primary route of exposure to airborne environmental insults

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Interestingly, the phosphodiesterase inhibitor Cilostazol (used in peripheral vascular disease treatment) is able to improve cognitive function in mice by increasing the hippocampal production of IGF-I through stimulation of sensory neurons [350]

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