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Animal studies also demonstrate the significant benefit of optimizing the levels of both GSH and VD-regulatory genes at the cellular/tissue level, in increasing 25(OH)-vitamin D levels and in reducing oxidative stress, TNF, and inflammation biomarkers in the circulation following co-supplementation with vitamin D and l-cysteine compared with vitamin D alone supplementation

These treatments had low rates of efficacy (5%-20%), high morbidity and mortality and are rarely used today

AGC1 and GC1 There are two carriers for aspartate and glutamate in mitochondria, namely AGC1 (SLC25A12 or Aralar1) and AGC2 (SLC25A13 or citrin)

doi: 10.5897/AJPP11.568 313 EdoGIMafeANRazooqiNFUmeloECGaazTSIsojeEFet al