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A major limitation for translating NRF2-targeted strategies into clinical practice is the substantial genetic and molecular heterogeneity of HCC, which is due to diverse etiologies and distinct oncogenic alterations

By inhibiting this enzyme, A1AT decreases the production of superoxides, contributing to a reduction in the overall ROS burden in tissues and helping to limit oxidative damage ( Furthermore, A1AT binds to metal ions such as copper (Cu) and iron (Fe), which catalyze ROS production via the Haber-Weiss and Fenton reactions

Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB