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Upon exposure to oxidative stress or electrophiles, Nrf2 translocate to the nucleus where it binds to antioxidant responsive elements (ARE)
Conclusions In conclusion, our results indicate that maintenance of hepatic GSTA1 levels leads to a decrease in FABP1 levels, thereby improving hepatic steatosis, which represents an interesting approach for exploring GSTA1 stabilizers or enhancers as a new class of drugs against MASLD in the future
and Frye, R.E., Frontiers in Physiology , 2014, vol
Neurons rely on astrocytes for cholesterol synthesis, fatty acid detoxification, lipid droplet management and redox balance
