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[35] Medical uses [edit] European Union [edit] In the European Union, semaglutide is indicated for the treatment of adults with insufficiently controlled type 2 diabetes as an adjunct to diet and exercise as monotherapy when metformin is considered inappropriate due to intolerance or contraindications, [16] [17] in addition to other medicinal products for the treatment of diabetes

Simultaneously, it activates extracellular signal-regulated kinase (ERK1/2) pathways while reducing pro-inflammatory nuclear factor kappa B (NF-B) signaling a combination that supports tissue recovery while managing inflammation

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This mechanism regulates epithelial cell polarization, which plays an important role to maintain physiological functions, such as tissue barrier and gas exchange in healthy epithelial cells