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G.AmbsS.CimminoA.PetroccaF.et al (2006)

Initial reports documented active sphingolipid metabolism of C2:0 and C6:0 ceramides to Sph and S1P in differentiated oligodendrocytes (Qin et al., 2010)

Advanced imaging techniques including confocal microscopy and in vivo imaging are revealing real-time effects on cellular processes including cell migration, angiogenesis, and tissue remodeling

Induced pluripotent stem cell (iPSC)-derived human liver organoids (iHLOs) are particularly promising, as they can recapitulate the cellular complexity of the liver, including diverse cell types such as hepatocytes, cholangiocytes, endothelial cells, and occasionally Kupffer cells 11