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In healthy CNS tissue, urea metabolism is non-cyclic, whereas it becomes fully cyclic upon exposure to -amyloid

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Study A matched participants 1:1 to receive either placebo or bremelanotide subcutaneously three times daily for 15 days (1.25 mg/1.00 mg/1.00 mg on day 1 and 2.5 mg/2.0 mg/2.0 mg on following days), and Study B assigned participants to receive either once-a-day (2.5 mg) or twice-a-day (2.5 mg/2.0 mg) doses of bremelanotide versus placebo for four days

Mol Cell 11:619633 Hargreaves IP (2003) Ubiquinone: cholesterols reclusive cousin