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In 5 times batch repeated reaction with a 1,000 mL reaction volume using the sponge as the carrier, whose cost would be 2,400 USD, 61 g -EC would be produced, which is equivalent to approximately 226,000 USD estimated from the current market price

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medRxiv 2021

When selecting the exposure concentration, it is also important to consider other physiological factors, such as the route of administration and distribution, and pharmacological factors, such as Cmax, to prevent the use of unrealistic exposure scenarios (Xu et al., 2020)