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In a healthy dog, the pancreas, intestines, liver, and kidneys are all needed to properly absorb and store this B12

The goal is proximity without injecting directly into compromised or inflamed tissue

This rebound effect contributes significantly to weight regain patterns observed after cessation of appetite-modifying medications

Pralatrexate: 1 (milligram) mg of vitamin B12 as an injection no more than 10 weeks prior to the first dose and every 8 to 100 weeks thereafter
