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doi: 10.1046/j.1440-1746.2003.03156.x

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Cagrilintide, a long-acting amylin analogue: pharmacology and receptor activity

Inflammation upregulates hepcidin, promoting the internalization and degradation of the iron exporter ferroportin (FPN), thereby effectively blocking cellular iron efflux ( Clinical studies have confirmed that ferritin levels in GCF are significantly elevated in periodontitis patients and positively correlate with probing depth (PD) and clinical attachment loss (CAL) ( 2+ catalyzes the Fenton reaction, generating highly reactive hydroxyl radicals that provide the initial chemical driving force for the chain reaction of lipid peroxidation ( 2.2 Lipid metabolic reprogramming and lethal peroxidation execution The execution of ferroptosis is fundamentally driven by lethal peroxidation of membrane lipids, a process involving a series of active lipid metabolic reprogramming events