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Description

This alternative hypothesis proposes arrestin-driven receptor-G protein uncoupling (desensitization) as the mechanism responsible for the loss of morphine's analgesic action, which is in turn exacerbated by receptor failure to internalize and undergo resensitization [38, 39]

Pieters et al

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Different studies (as mentioned in Section 7.2) suggest that cardamom effectively represses the up-regulation of IL-6, IL-8, and MCP-1, as well as the activation of NF-B and Stat3