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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

Clin Chim Acta 216:135143 Lloyd-Still JD, Powers CA, Wessel HU (1993) Carnitine metabolites in infants with cystic fibrosis: a prospective study

PMID 8209928

reported that plasmid-encoded IL-28B significantly enhanced antigen-specific CD8+ T cell responses in a therapeutic HPV16 DNA vaccine targeting E6 and E7 oncoproteins in mice ( + T cell responses and improved both prophylactic and therapeutic control of E6/E7-expressing tumors in mice