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The model predicts synergistic efficacy for combination of AXT050 with sorafenib, cabozantinib, and rilotumumab but not synergistic potency We next used the calibrated and validated model to investigate the effect of the combination of AXT050 with other therapeutics targeting HGF/Met signaling pathway to predict synergy

Placing the formulation against the inner cheek (buccal placement) is second-best but has thicker tissue and lower absorption rate