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Cell Stem Cell 25 , 531541.e6 (2019)
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The nuclear transcription factor NEF2 serves as an inducer of SLC7A11 expression, while tumor suppressor genes TP53, BAP1, and BECN1 downregulate SLC7A11 expression [40,41,42]
Inhibition by VopS is believed to be a result of AMPylation of the RhoGTPase Rac by this effector, effectively blocking it from interacting with other members of the NADPH oxidase complex (Woolery et al., 2014)
