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It is not clear why this side-effect of statins occurs in some but not all patients taking this medication
On the basis of this finding the authors suggested the pathway shown in Figure 3A, according to which glucose-derived -ketoglutarate leaves the astrocytic TCA cycle in exchange with malate, generated via oxaloacetate (OAA), which in turn had been formed from aspartate in a transamination process
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It turns out that restricting calories in some animals also preserves the rhythm of melatonin production
