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Discovering the landscape of protein modifications
In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)
Since vitamin B12 is primarily found in animal products, individuals following a plant-based diet may be at risk of deficiency
