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Two predominant hypotheses have emerged: the outside-in model, where peripheral immune activation drives CNS demyelination, and the inside-out model, which posits that primary glial or axonal injury triggers the disease
L-arginine plays a pivotal role in metabolic pathways encompassing pyrimidine metabolism, arginine biosynthesis, and the mammalian target of rapamycin (mTOR) signaling pathway
[DOI] [PubMed] [Google Scholar] 191.Lundquist F, Wolthers H
Melnyk, M
