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PLoS ONE 9 , e89246 (2014)

[ref] In summary, knowing your risk factors may help you figure out whether acetaminophen is a safe choice for you as a pain reliever when using it at higher doses or for longer periods of time

There is also a difference in enzymes that metabolize alcohol in womens bodies, so it generally doesnt metabolize as fast, and the alcohol stays in their bodies for a longer time

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