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doi: 10.1038/s41419-021-03535-9

described a rare mutation in APP, near the Cys-rich domain, that generates an increase in A production related to a fast exit of APP from the endoplasmatic reticulum (ER) (Zhang et al., 2021)

Afterward, the urothelium of the mice was extracted and studied for the expression of inflammatory markers such as connexin 43 (Cx43) protein
