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Consequently, vigilance during clinical practice is paramount for the diagnosis and treatment of toxicities related to THC in children

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Its advantages due to in vitro and in vivo animal studies include: its extremely high potency, oral absorptivity, short duration of action, no long-term deposition in tissues, minimal interference with hemoproteins, and minimal effects on HO-1 gene expression and subsequent protein synthesis

Analysis of the relative gene expression revealed that animals that received only BLM challenge by oropharyngeal administration (induced group) showed a significant reduction in the expression of Nrf2 (P = 0.01) and PPAR- mRNA (P = 0.04)