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Analysis of the Ycf1 prediction shows a close recreation of the cryo-EM structures shown here, with a strikingly similar organization of the R-domain as the IFwide and IFnarrow structures

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The subjects were divided into four treatment groups: [1] Control group (vehicle) Low-dose paraxanthine (equivalent to 25mg human dose) High-dose paraxanthine (equivalent to 100mg human dose) High-dose caffeine (equivalent to 100mg human dose) To assess cognitive function, the researchers employed the Morris water maze test , a well-established method for evaluating spatial learning and memory