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Clinical trials aimed at HBV cure Efficacy endpoints for clinical trials Initial trials of IFN and NA used biochemical, virological, serological, and histological endpoints to assess efficacy, while more recent trials have focused on virological and serological endpoints because these endpoints have been shown to correlate with improved clinical outcomes.[36], [77], [78], [79] The use of a biochemical endpoint is problematic because of the lack of a standardised definition of normal ALT

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