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10.1039/c7cs00827a

Other symptoms to note : The rash is accompanied by flu-like symptoms, including high fever, cough, and runny nose

For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]