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SIRT1 relies on nicotinamide adenine dinucleotide to deacetylate and serve as a nutrient deficiency sensor (267)

4 Research progress of the serine synthesis pathway in pan-cancer The transcriptional expression differences of key enzymes in the de novo serine synthesis pathway (including PHGDH, PSAT1 and PSPH) across pan-cancer specimens were systematically analyzed using the Timer online database ( Figure 2 ), revealing the expression heterogeneity and potential tumor-specific expression patterns of these enzymes in distinct cancer types

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